The only team with an unblemished record in the English Premier League, Everton lost to Southampton at the St Mary’s Stadium 2-0.
The Toffes have have been impressive with the acquisition of James Rodriguez, Allan and Doucoure giving them a lift.
Southampton, who earned a last-minute draw against Chelsea at Stamford Bridge penultimate weekend dealt Everton a huge blow.
Two first-half goals from James Ward-Prowse and Che Adams gave the Saints the maximum points, Lucas Digne was sent off for Everton in the 72nd minutes.
Jamie Vardy came off the bench to score the winning goal for Leicester City against Arsenal at the Emirate Stadium.
The match ended 1-0 in favour of Leicester City, Vardy has now scored 11 goals in 13 matches against Arsenal.
Arsenal defender David Luiz limped off in the first half, Lacazette’s goal was ruled out to cap a frustrating evening for the Gunners.
Vardy scored a sublime header in the 80th minute to hand Leicester City the maximum points.
Brighton and West Brom will slug it out at the Ammex Stadium, while Tottenham visits Burnley on Monday night.