The 21-year-old has been impressive for the club this season as they open up a 10 points gap over Real Madrid and Barcelona with a game in hand.
He will self-isolate at home according in line with the league’s covid-19 protocol.
Felix is the third Atletico Madrid player to contract Covid-19 after Yannick Carrasco and Mario Hermoso tested positive last week.
The trio are set to miss Monday’s home game against Celta Vigo.
Felix has scored six goals and recorded five assists in 18 Laliga appearances this season.