Liverpool and Manchester City played out a 1-1 draw at the Etihad Stadium.
Mohammed Salah opened the scoring for the visitors from the spot after Saido Mane was fouled by Kyle Walker.
Few minutes later, Gabriel Jesus took advantage of a lack of coordination from the Liverpool defenders to level the scores.
De Bruyne missed a crucial penalty awarded to Manchester City just before half-time when Gomez was adjudged to have handled the ball in the 18-yard box.
Gabriel Jesus missed a glorious chance to hand City the maximum point in the closing stages of the match.
Liverpool are in the third position on the Premier League log, while Man City are in the 10th position.
Aston Villa recorded a stunning 3-0 victory over Arsenal at the Emirates Stadium.
Bukayo Saka diverted into his own net to open the scoring for the visitors in the first half.
Ollie Watkins, who scored a hat-trick against Liverpool scored two goals in three second-half minutes to condemn Arsenal to another home loss.
Arsenal had only two shots on target while star striker, Aubameyang failed to have any shot in target as his poor form continues.
Tottenham earned a hard-fought 1-9 win over West From courtesy of a lone goal by Harry Kane.
Premier League action resumes on November 21 after the international break.